GLP-1 weight-loss drugs alter brain circuits in the amygdala and dopamine system to reduce the motivation to seek out high-calorie foods.

We have long been told a simple story about reward: Dopamine is the "wanting" molecule that drives us toward goals, and opioids are the "liking" molecules that provide the hit of pleasure once we get ...

Scientists are uncovering how hunger circuits in the brain, especially AgRP neurons, directly influence reward pathways, making food—and even non-caloric treats—more appealing. These neurons not only ...

Positive thinking may boost the body’s defenses against disease. Increasing activity in a brain region that controls motivation and expectation, specifically the brain’s reward system, is linked with ...

Editor’s note: The podcast Chasing Life With Dr. Sanjay Gupta explores the medical science behind some of life’s mysteries big and small. You can listen to episodes here. (CNN) — If you are like many ...

I was a third-year medical student at Northwestern on my ICU rotation the first time I saw a dopamine drip. The patient was pale and motionless, his blood pressure dropping by the minute despite large ...

A new study is challenging one of neuroscience’s most enduring ideas: that the brain’s reward system exists to make us feel good. Instead, researchers argue that it is built to optimize energy.