Preconception radiation exposure alters offspring mitochondrial DNA in an organ-specific manner

It did not take long after the discovery of X-rays in the 1890s for scientists to begin exploring the harmful effects of radiation on living organisms. Yet even after more than a century of research, ...
News Medical

Study reveals association between ribosomal DNA copy number and disease risk

Ribosomal DNA (rDNA) is present in hundreds of copies in the genome, but has not previously been part of genetic analyses. A new study of 500,000 individuals indicates that people who have more copies ...
ascopubs.org

Tumor fraction and copy number burden from urinary cell-free tumor DNA (utDNA) to predict minimal residual disease prior to repeat-transurethral resection in high-risk non ...

A multi-institutional observer study of AI-aided oncologists' performance on treatment response assessment of bladder cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This ...
ascopubs.org

HER2 Protein Overexpression, mRNA Expression, and DNA Amplification Across Solid Tumors: Comparison of Next-Generation Sequencing–Based Assays With Immunohistochemistry

Real-World Plasma Thymidine Kinase Activity in High-Risk and Metastatic Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer Treated With Cyclin-Dependent Kinase ...
Medical Xpress

DNA Copy Number Variations

Genetic ancestry plays a key role in determining the behavior of head and neck tumors and may help explain why African-American patients survive for half as long as their counterparts of European ...
EurekAlert!

mtDNA copy number contributes to growth diversity in allopolyploid fish

Understanding the relationship between mtDNA and animal growth could provide valuable information for selective breeding in aquaculture. However, the complex interactions between genetics and ...