Objectives Owing to the underrepresentation of early-stage disease in randomised trials and inconsistent clinical evidence, ...

The target trial framework provides a systematic approach for designing observational analyses that attempt to emulate a hypothetical pragmatic trial. This process requires that investigators specify ...

Researchers used real-world clinical data to attempt to emulate a randomized controlled trial testing the effectiveness of two blood thinners, apixaban and warfarin, to prevent stroke in patients with ...

About The Study: Application of the Transparent Reporting of Observational Studies Emulating a Target Trial (TARGET) guideline recommendations aims to improve reporting transparency and peer review ...

Breast cancer survivors who maintain an exercise routine suited to their personal needs may improve their long-term survival, a new study suggests. The study, designed as a so-called target trial ...