Normal populational variations of DNA sequence, also called genetic polymorphisms, underlie the intraspecies phenotypic variability. In human, single-nucleotide polymorphisms (SNPs) affect ...
Polymorphisms in epidermal growth factor (EGF) and proteinase activated receptor 1 (PAR-1) associated with tumor recurrence in localized adenocarcinoma (EA) of the esophagus treated with surgery alone ...
Tamoxifen reduces the rate of breast cancer recurrence by approximately a half. Tamoxifen is metabolized to more active metabolites by enzymes encoded by polymorphic genes, including cytochrome P450 ...
The impact of preoperative dexamethasone on long-term survival following surgery for colorectal cancer. Genetic variants in methylation and demethylation pathways to predict clinical outcome in ...
Scientists headed by a team at the University of Chicago have shown how genetic differences in the immune system can impact on the types of bacterial communities that colonize the gastrointestinal ...
Several mutations in a single gene can cause the rare and hard-to-diagnose syndrome, known as catacholamineric polymorphic ventricular tachycardia (CPVT). CPVT strikes children during physical ...
Dr. Daniel Geraghty is a geneticist who studies the roles of genes and related molecules in the immune system’s response to disease. His team develops new laboratory tools, software and techniques to ...
Why some people develop major depressive disorder and others do not is a complex and not well-understood process. Several factors have been discussed to contribute to depression, among them: Genetic ...
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