The customary approach to early-phase clinical trial design, where the focus is on identification of the maximum tolerated dose, is not always suitable for noncytotoxic or other targeted therapies.

This is a preview. Log in through your library . Abstract The posterior probability of linkage (PPL) is a Bayesian statistic which directly measures the probability of linkage between a trait locus ...

As for whether the trial established that simvastatin is beneficial, the trial was stopped early because of a low likelihood of reaching prespecified stopping criteria, as a result of decreasing ...