A research group has developed an engineered E. coli strain that converts formic acid and CO2 to pyruvate and produces cellular energy from formic acid through reconstructed one-carbon pathways. The ...

Endogenous pyruvate is an end-product in glycolysis and a key molecule for ATP production under aerobic and anaerobic conditions, whereas exogenous pyruvate is transferred to cells via monocarboxylate ...

Osaka, Japan - Serine racemase (SRR) is a multifunctional enzyme that carries out several different reactions in human cells, including the conversion of L-serine into pyruvate. Despite already being ...

The results of the glycerol kinase studies are somewhat surprising in light of good evidence from several laboratories that mitochondrial metabolism of glucose generates important signals for insulin ...

Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as ...

The metabolic adaptations that cancer cells make to survive also present new drug opportunities, a new study shows. The study, published in Molecular Cell, suggests that targeting a vitamin ...

Glycolysis is a term used to describe the metabolic pathway involving the degradation of glucose into pyruvate and energy used to form adenosine triphosphate (ATP) and reduced nicotinamide adenine ...