E. coli RecBCD is a DNA helicase with two ATPase motors (RecB, a 3′→5′ translocase, and RecD, a 5′→3′ translocase) that function in repair of double-stranded DNA breaks. The RecBC heterodimer, with ...
In this issue, Wu et al. show that the RecBC helicase, which is involved in repairing double-strand DNA breaks, uses one ATPase motor to drive two translocases along opposite strands of DNA—much as an ...
New research shows that the nuclease domain of the E. coli RecBCD helicase plays a key role in regulating DNA binding and the extent of base pair melting during double-strand break repair. Deleting ...
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