Scientists from the Perelman School of Medicine at the University of Pennsylvania and their colleagues have identified a cell surface receptor protein called TIE2 as a critical component of two key ...

A gene called ZNRF3, known to be involved in cancer, also messes with the mind. The human brain relies on two copies of this gene to build a right-sized brain. If one of the copies is defective, the ...

“Further analysis showed that these genes are involved in several essential biological processes, including developmental signaling, energy production, ion balance, and cell growth.” In particular, ...

Amyotrophic lateral sclerosis (ALS) is a serious and usually fatal neurodegenerative disorder in which motor neurons deteriorate and die. The disease causes a loss of movement that eventually affects ...

Microscopic images of cranial blood vessels show the growth of mulberry-shaped CCMs over a 21 day period in control mice (top two rows). This growth is prevented by treatment with the TIE2 inhibitor ...

A growing body of preclinical research points to the TIE2 receptor and its angiopoietin ligands as a promising drug target for brain blood vessel defects, including arteriovenous malformations, venous ...