Orally administered drugs have to pass through the gut wall mucosa before they may reach the capillaries that lead to the portal vein. This barrier consists of polarized enterocytes that are closely ...

During drug development, researchers need to perform adequate nonclinical testing to ensure a drug’s safety and efficacy before starting clinical trials. An important aspect they must evaluate is a ...

Biopharmaceuticals, medium- and high-molecular weight biologically active macromolecules, are not easily absorbed by the small intestine, the main organ responsible for gastrointestinal absorption, ...

From the foregoing remarks on the association of uremia and pyelonephritis it can be seen that in clinical medicine aluminum hydroxide and antibiotics are frequently used simultaneously in advanced ...

The fact that several substances that function as OATP inhibitors are at the same time inhibitors or inducers of CYP enzymes and other transporters hampers the clarification of an involvement of OATPs ...

New research shows that certain flavonols from everyday foods can shut down the body’s drug-resistance machinery, potentially paving the way for more effective treatments, but clinical hurdles remain.

In this interview, Karl Box discusses how particle drift analysis using flux tools improves oral drug absorption in pharmaceutical research. Can you tell us about Pion’s Rainbow Dynamic Dissolution ...

The way in which the body processes cholesterol affects the risk of cardiovascular diseases. LDL cholesterol is obtained from saturated fats in food and from hepatic cholesterol synthesis. Its ...