p27 (also known as KIP1, and encoded by CDKN1B) is regulated by multiple signal transduction pathways in normal and malignant cells. CDKN1B transcription can be regulated by the FoxO family and ...

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Here we show that the cell-cycle regulator p21 is involved in immune system function. T lymphocytes from p21 −/− mice exhibit significant proliferative advantage over wild-type cells following ...