Companies are adopting diverse approaches to reducing unwanted toxicities associated with cell and gene therapy.

This review explains how glucose scarcity, lipid disruption, amino acid deprivation, and toxic metabolites weaken CAR-T cells ...

The development of an embryo is one of the most fundamental processes in biology. Early in this process, it is determined ...

Cellular homeostasis and stress response are tightly coordinated processes involving a complex interplay between signaling ...

A new study published in Engineering provides mechanistic insights into live-cell glycocalyx engineering and supports the rational design of next-generation adoptive cell therapies (ACTs) against B ...

Most gene-editing tools cut DNA wherever they’re pointed, with no way to tell a tumor cell from a healthy one. A study ...

DNA does not float freely in the cell. Instead, it is wrapped around histone proteins to form structures called nucleosomes.

A detailed analysis of T-cell redirecting therapies in oncology, comparing the mechanisms of bispecific antibodies and CAR T ...

As we go about our day, the trillions of cells in our bodies run like well-oiled machines: continually sensing what's ...

A robust and quantitative map links chromatin modification and gene expression of cells during zebrafish embryogenesis.

UC San Diego researchers have developed a new method that allows precise modification of any microbiome with prebiotics, ...