From Process Development to Manufacturing: Optimize and Scale up the AAV Enrichment Step
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From Process Development to Manufacturing: Optimize and Scale up the AAV Enrichment Step
Adeno-associated viruses (AAV) have emerged as leading vectors for gene therapy applications due to their low pathogenicity and ability to mediate long-term gene expression in a wide range of tissues. In each AAV downstream process, one of the key steps (and often a bottleneck) is enrichment of full capsids. Along with scalability and capsid ...
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